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Urate urolithiasis and hyperuricosuria in a Weimaraner, secondary to the SLC2A9 transporter defect
  1. Jodi L. Westropp1,
  2. Eric G. Johnson2,
  3. Mark C. Fuller2,
  4. Noa Safra3 and
  5. Danika L. Bannasch3
  1. 1Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California-Davis, One Shields Avenue, Davis, CA 95616,USA
  2. 2Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, One Shields Avenue, Davis, CA 95616,USA
  3. 3Department of Population Health and Reproduction, School of Veterinary Medicine, University of California-Davis, One Shields Avenue, Davis, CA 95616,USA
  1. Correspondence to Dr Jodi L. Westropp, jlwestropp{at}ucdavis.edu

Abstract

In this case, we describe a middle-aged, male Weimaraner that presented with upper and lower urinary tract urate urolithiasis. The dog required surgical intervention to remove the obstruction in the right ureter as well as medical management to prevent recurrent calculi. While the genetic defect that causes this disease in Dalmatians is well known among clinicians, this is the first clinical case documented in the Weimaraner breed. This dog shared the same SLC2A9 mutation as Dalmatians, which likely predisposed this dog to developing urate calculi. For dogs where urate uroliths are suspected on imaging studies, genetic testing may be warranted to help elucidate any predisposing factors for stone formation. Knowing the aetiology of the stone formation will alter the therapeutic approach for treatment and management.

  • Urinary tract
  • Dogs
  • Genetics

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