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Sheep and goats
Closantel toxicity in a pregnant ewe at mid gestation: the pathological evaluation of the ewe and lamb nine months later
  1. Fergus Patrick Hannon1,
  2. Kathryn Amanda Ellis1,
  3. Julien Guevar2,
  4. Francesco Marchesi2,
  5. Timothy Geraghty1 and
  6. Joshua David George Leach2
  1. 1Scottish Centre for Production Animal Health and Food Safety, School of Veterinary Medicine, College of Medical Veterinary and Life Sciences, University of Glasgow,
  2. 2School of Veterinary Medicine, College of Medical Veterinary and Life Sciences, University of Glasgow, Bearsden Road, Glasgow G61 1QH, UK
  1. Correspondence to Fergus Patrick Hannon, 2106803h{at}student.gla.ac.uk

Abstract

In February 2013, a flock of 20 pastured ewes was treated with oral closantel. Within 10 days of dosing, one 2-year-old Texel-cross ewe that was approximately three months in lamb was noticed to be spending a prolonged time in recumbency. On the 6th of March, the animal was referred to Scottish Centre for Production Animal Health and Food Safety (SCPAHFS). At admission, the ewe appeared blind, pupils were dilated with a negative menace response and pupillary light reflex bilaterally. Closantel toxicity was suspected. Following admission, this ewe was housed and was stable despite remaining blind. On April 21, a single male lamb was born. This lamb was found to have normal clinical and neurological parameters over five months of observation following birth. On postmortem examination closantel toxicity was confirmed in the ewe while following detailed gross and histological examination of all tissues of the lamb there was no indication of the toxicity suffered by its mother.

  • salicylanide
  • toxicity
  • ovine
  • gestation

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