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Cats
Treatment of a case of feline infectious peritonitis with cyclosporin A
  1. Yoshikazu Tanaka1,
  2. Yuka Sato2,
  3. Daiki Takahashi3,
  4. Hirotaka Matsumoto4 and
  5. Takashi Sasaki5
  1. 1Department of Veterinary Hygiene, Veterinary School, Nippon Veterinary & Life Science University, Musashino, Tokyo, Japan
  2. 2Division of Molecular Virology, Department of Microbiology and Immunology, The University of Tokyo, The Institute of Medical Science, Minato-ku, Tokyo, Japan
  3. 3Division of Molecular Virology, Department of Microbiology and Immunology, Daiki Animal Hospital, Katsushika-ku, Tokyo, Japan
  4. 44Department of Veterinary Internal Medicine, Veterinary School, Nippon Veterinary & Life Science University, Musashino, Tokyo, Japan
  5. 5Faculty of Medicine, Department of Bacteriology, Juntendo University, Bunkyo, Tokyo, Japan
  1. Correspondence to Dr Yoshikazu Tanaka; ytanaka{at}nvlu.ac.jp

Abstract

Feline infectious peritonitis is a fatal viral disease which is currently incurable by drugs. Also, there are no effective vaccines. Cyclosporin A (CsA) was recently shown in vitro to exert potent antiviral activities on several virus-host systems, including various coronaviruses. However, whether CsA has clinically relevant activity in vivo resistant to various coronaviruses, including the severe acute respiratory syndrome and Middle East respiratory syndrome coronaviruses, remains unknown. Herein, the authors report that treatment with CsA caused a sustained reduction in pleural fluid volume and viral copy number in a cat diagnosed with effusive feline infectious peritonitis.

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  • Received August 30, 2014.
  • Revision received January 13, 2015.
  • Accepted January 14, 2015.
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