Article Text

PDF

Cats
Extensive small intestinal wall thickening in a cat
  1. Ana Rita Ramalho Furtado1,
  2. Jordi Puig2,
  3. Roberta Rasotto2 and
  4. Mauro Pivetta3
  1. 1Swayne and Partners, Newmarket, Suffolk, UK
  2. 2Animal Health Trust, Newmarket, Suffolk, UK
  3. 3NDSR, Bletchingley, UK
  1. Correspondence to Dr Ana Rita Ramalho Furtado, rita.ramalho.furtado{at}gmail.com

Statistics from Altmetric.com

Description

A two-year-old domestic shorthair cat presented for investigation of a six-month history of intermittent vomiting, weight loss, hyporexia and lethargy. Abdominal ultrasound was performed and revealed extensive small intestinal wall thickening (average thickness measured 8 mm) with preserved layering. In particular, there was marked thickening of the muscularis propria layer (variable thickness from 4 to 5 mm) with normal mucosal and submucosal layers (Daniaux and others 2014), Overall, there was normal intestinal peristaltic activity and no evidence of intestinal obstruction.

The ultrasonographic changes were consistent with intestinal smooth muscle hypertrophy such as seen with severe diffuse inflammatory infiltrative bowel disease or a diffuse neoplastic intestinal disease such as lymphoma (Fig 1) (Zwingenberger and others 2010 and Diana and others 2003).

FIG 1:

Linear probe transverse plane image through a segment of small intestine illustrating severe muscularis intestinal wall thickening

Full-thickness biopsies of duodenum, jejunum and ileum were collected. Histopathology confirmed the thickening of the intestinal wall due to marked expansion/thickening of the muscularis with mild fibrosis and inflammation in the mucosa. The tunica muscularis was approximately five times (inner layer four times, external layer one time) thicker than the submucosal layer (Fig 2). Immunohistochemistry for CD3 and CD79a demonstrated that the lymphoid population infiltrating the intestinal mucosa was composed of an admixture of T and B lymphocytes ruling out lymphoma.

FIG 2:

(a) Histopathology of the duodenum. The tunica muscularis (asterisk) appears approximately five times thicker than the submucosa (dagger). H&E stain; bar=400 µm. (b) Linear probe longitudinal plane image of the duodenum, illustrating the same muscularis thickening as seen on (a)

In this case, ultrasound was proven to be an essential means of diagnosis showing similar muscularis characteristics as the ones seen on histopathology (Fig 2). However, full-thickness surgical biopsy followed by histopathology and immunohistochemistry are mandatory to reach a final diagnosis.

  • Received December 17, 2014.
  • Revision received January 6, 2015.
  • Accepted January 12, 2015.

References

View Abstract

Footnotes

  • Contributors All the authors have given final approval of the submitted manuscript for which all take public responsibility for the whole content. All the authors qualify for authorship based on making one or more of the substantial contributions to the intellectual content, conception and design, acquisition of data and analysis and interpretation of data. Furthermore, ARRF has participated in drafting of the manuscript, while JP was responsible for critical revision of the manuscript for important internal medicine content, RR for the histopathology content and MP for the diagnostic imaging content.

  • Competing interests None.

  • Provenance and peer review Not commissioned; externally peer reviewed.

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.