A nine-year-old Italian Spinone dog presented with a history of urinary incontinence associated with polyuria/polydipsia (PUPD). Haematology and serum biochemistry identified hypercalcaemia. Subsequently, thoracic radiographs, abdominal ultrasound, urinalysis, serum assay of parathyroid hormone (PTH) and PTH-related protein concentrations and ultrasound of the parathyroid glands were consistent with a diagnosis of primary hyperparathyroidism. Unusually, however, all four parathyroid glands were noted to be enlarged on ultrasound, as opposed to a single parathyroid nodule (commonly an adenoma) as is normal in primary hyperparathyroidism. This presented a dilemma as to how best treat the dog; ultimately, two out of four parathyroid glands were removed. Postoperatively, normocalcaemia returned, and PUPD and incontinence resolved. Histopathological examination of the two removed glands was consistent with nodular hyperplasia of chief cells for one gland and nodular hyperplasia of chief cells and oxyphilic cells for the other gland, confirming a diagnosis of parathyroid hyperplasia.
- parathyroid gland
- Received March 12, 2015.
- Accepted June 18, 2015.
- British Veterinary Association
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.