Article Text

PDF
Haemophagocytic syndrome in a dog with granulomatous splenitis
  1. Austin K Viall,
  2. Shannon M McLeland,
  3. Erin R McQuinn,
  4. Louisa K Ho-Eckart and
  5. Chad M Johannes
  1. Veterinary Pathology, Iowa State University College of Veterinary Medicine, Ames, Iowa, USA
  1. Correspondence to Dr Austin K Viall; akviall{at}iastate.edu

Summary

A golden retriever dog was evaluated for cranial abdominal organomegaly. Clinical investigation found concurrent splenomegaly, anaemia, thrombocytopenia, hypoalbuminaemia and hypocholesterolaemia. Cytological evaluation of splenic aspirate samples identified a population of atypical, erythrophagocytic, mesenchymal cells. Due to the patient’s signalment, clinicopathological abnormalities and splenic cytological findings, the dog was suspected to have haemophagocytic histiocytic sarcoma. Splenectomy with splenic histopathology was performed to confirm the diagnosis. Histologically, granulomatous splenitis with erythrophagocytic macrophages was identified; a cause for splenitis was not identified. The dog was clinically diagnosed with reactive haemophagocytic syndrome secondary to splenitis. The patient clinically decompensated a month postsplenectomy and was euthanased.

Statistics from Altmetric.com

  • Received October 18, 2016.
  • Revision received November 16, 2016.
  • Accepted December 7, 2016.
View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.