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Caudoventral abdominal lymphangiosarcoma in a cat treated with metronomic chemotherapy
  1. Jorge Castro-López1,
  2. Nuria Bermúdez2,
  3. Jorge Martínez3,
  4. José Ramos-Varas4,
  5. Marta Planellas1 and
  6. Josep Pastor1
  1. 1Department of Animal Medicine and Surgery, Facultat de Veterinària, Universitat Autònoma de Barcelona, Barcelona, Spain
  2. 2Hospital Veterinari Balmes, Barcelona, Spain
  3. 3Department of Animal Health and Anatomy, Facultat de Veterinària, Universitat Autònoma de Barcelona, Barcelona, Spain
  4. 4Animal Disease Diagnostic Laboratory, Department of Comparative Pathobiology, Purdue University College of Veterinary Medicine, West Lafayette, Indiana, USA
  1. Correspondence to Jorge Castro López, e-mail: jorgecastro77{at}


A 10-year-old, male neutered domestic shorthair cat was referred for reddish discolouration of its abdominal skin with serosanguineous discharge. The affected skin was bruised, nodular and had fluid-filled cavities. It was painful on palpation. A final diagnosis of lymphangiosarcoma was made by prospero-related homeobox gene-1 (PROX-1) immunohistochemistry. Metronomic chemotherapy treatment was instaured with toceranib phosphate, chlorambucil and meloxicam. Partial remission was achieved at 18 days and stable disease was maintained for 36 days (survival time: 54 days). Afterward, the tumour began to regrow aggressively and the patient developed anorexia; owners elected for euthanasia. Total survival time achieved was 63 days. To the authors’ knowledge, this is the first case report of feline caudoventral abdominal lymphangiosarcoma treated with metronomic chemotherapy.

  • Cats
  • Dermatopathology
  • Immunopathology
  • Neoplasia
  • Skin
  • Abdominal
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