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Retinopathy and optic neuropathy following closantel treatment of ewes
  1. James Patrick Crilly,
  2. Jorge del Pozo,
  3. Philip R Scott,
  4. David J Wilson,
  5. Neil D Sargison and
  6. Isabelle Truyers
  1. Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian EH25 9RG
  1. Correspondence to James Patrick Crilly, jcrilly{at}


An outbreak of sudden onset blindness subsequent to dosing with oral closantel affecting 1 per cent of a six hundred ewe flock was investigated. Clinical examination and histopathology both revealed features fully consistent with closantel toxicity despite the maximum dose received by the affected sheep not exceeding 14.5 mg/kg (recommended dose rate 10 mg/kg). The interval between dosing and the onset of clinical signs had been recorded accurately (minimum interval eight days) and was found to be longer than in previous reports.

  • Sheep
  • Toxicology
  • Central Nervous System (CNS)
  • Eyes
  • Liver Fluke
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