A five-year-old neutered male Staffordshire bull terrier was referred with a one-month history of lethargy and ataxia. Neurolocalisation was to the left forebrain with suspected increased intracranial pressure. MRI demonstrated a mass lesion in the caudal right and left nasal cavities extending through the cribriform plate into the rostral cranial fossa infiltrating the left olfactory bulb and left frontal lobe. Severe diffuse meningitis of the brain and cranial cervical spinal cord characterised by disseminated avidly enhancing meningeal nodules was present. At postmortem examination, the mass was multilobulated and firm; histologically, it was composed of pyogranulomatous and eosinophilic inflammation associated with large numbers of encapsulated yeast-like organisms, consistent with a nasal cryptococcoma. Fungal culture from a nasal swab confirmed Cryptococcus neoformans species. To the authors’ knowledge, this is the first case reported in the UK of a dog with nasal cryptococcoma causing severe meningitis.
- nasal cryptococcoma
- United Kingdom
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