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Primary hyperparathyroidism associated with hyperplasia of multiple parathyroid glands in a dog
  1. Florence Vessieres1,
  2. Aida Gomez Selgas2,
  3. Roberta Rasotto3 and
  4. Eleanor Raffan4
  1. 1Animal Health Trust, Newmarket, UK
  2. 2Department of Small Animal Internal Medicine, Animal Health Trust, Newmarket, UK
  3. 3Department of Pathology, Animal Health Trust, Newmarket, UK
  4. 4University of Cambridge Metabolic Research Laboratories, Cambridge, UK
  1. Correspondence to Eleanor Raffan, er311{at}


A nine-year-old Italian Spinone dog presented with a history of urinary incontinence associated with polyuria/polydipsia (PUPD). Haematology and serum biochemistry identified hypercalcaemia. Subsequently, thoracic radiographs, abdominal ultrasound, urinalysis, serum assay of parathyroid hormone (PTH) and PTH-related protein concentrations and ultrasound of the parathyroid glands were consistent with a diagnosis of primary hyperparathyroidism. Unusually, however, all four parathyroid glands were noted to be enlarged on ultrasound, as opposed to a single parathyroid nodule (commonly an adenoma) as is normal in primary hyperparathyroidism. This presented a dilemma as to how best treat the dog; ultimately, two out of four parathyroid glands were removed. Postoperatively, normocalcaemia returned, and PUPD and incontinence resolved. Histopathological examination of the two removed glands was consistent with nodular hyperplasia of chief cells for one gland and nodular hyperplasia of chief cells and oxyphilic cells for the other gland, confirming a diagnosis of parathyroid hyperplasia.

  • parathyroid gland
  • hyperplasia
  • hyperparathyroidism
  • dog

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