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Sheep and goats
Metastasising hepatic neuroendocrine carcinoma in a pygmy goat (Capra hircus hircus)
  1. Iris Völker1,
  2. Maya Kummrow2,
  3. Katja von Dörnberg3,
  4. Peter Wohlsein1 and
  5. Marion Hewicker-Trautwein1
  1. 1Department of Pathology, University of Veterinary Medicine Hannover, Germany
  2. 2Zoo Wuppertal, Wuppertal, Germany
  3. 3Zoo Hannover GmbH, Hannover, UK
  1. Correspondence to Dr Marion Hewicker-Trautwein, marion.hewicker-trautwein{at}


An adult, female pygmy goat showed clinical injury and later lameness caused by marked swelling and ulceration of the left lateral hind claw. Conservative treatments failed and due to the development of excessive granulation tissue the lateral claw was amputated. Histologically, a malignant tumour invading the dermis was diagnosed. Fourteen weeks after surgery the goat became recumbent, showed increased values of liver enzymes. Euthanasia followed for humane reasons. At postmortem examination, the liver tissue was almost completely replaced by a solid tumour mass. Additional neoplastic nodules were found in several organs and lymph nodes. Histological and immunohistochemical examination revealed a primary metastasising hepatic neuroendocrine carcinoma (PHNEC) expressing chromogranin A and neuron-specific enolase. Neuroendocrine carcinomas have not been described in goats yet. A metastasis in the claw was the first clinical sign observed in this case. Pedal tumour metastasis should be considered as a differential diagnosis for lameness in goats.

  • Abdominal
  • Pathology
  • Goats
  • Histopathology
  • Liver
  • Neoplasia
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