A 12-year-old, male-neutered cross-breed presented with vague, non-specific signs and was diagnosed with acute, undifferentiated leukaemia (AUL) following haematology, bone marrow cytology and flow cytometry. A complete haematological response to cyclophosphamide, epirubicin, vincristine and prednisolone chemotherapy was achieved; however, progressive disease was identified 13 weeks after diagnosis and euthanasia performed at week 15. AUL is a rare form of acute leukaemia in the dog, and while remissions can be achieved with chemotherapy, as with other acute leukaemias, the remission and survival times appear to be disappointing in most cases.
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