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Suspected anaphylaxis following intravenous amoxicillin clavulanate administration under general anaesthesia in nine dogs
  1. Daisy Norgate and
  2. Natalie Bruniges
  1. Department of Anaesthesia, University of Liverpool Small Animal Teaching Hospital, The Wirral, UK
  1. Correspondence to Miss Daisy Norgate, daisyn{at}


Nine dogs undergoing general anaesthesia for various procedures between April and May 2015 at the University of Liverpool Small Animal Teaching Hospital experienced suspected anaphylaxis following intravenous administration of 20 mg/kg amoxicillin clavulanate. Common clinical signs, which developed during or immediately after antibiotic administration, included periorbital and muzzle oedema, erythematous wheals and moderate to severe hypotension. Each of these cases was anaesthetised by different people so a standardised intervention protocol was not employed. However, treatment generally consisted of discontinuation of antibiotic administration, anti-histamine administration, intravenous crystalloid fluid therapy and sympathomimetic drugs depending on severity of hypotension. All nine dogs recovered uneventfully from general anaesthesia although some mild dermatological signs persisted for several hours after recovery. No long-term complications have been reported. The two most severely affected cases are described in detail in this report and the rest are summarised in Table 1.

  • Anaesthesia
  • Anaphylaxis
  • Amoxicillin Clavulanate
  • Antibiotic
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