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Primary peripheral primitive neuroectodermal tumour of the tongue in a peach-faced lovebird (Agapornis roseicollis)


Ewing's sarcoma and primitive neuroectodermal tumour (PNET) are extraordinarily rare. In human beings, these tumours have a common chromosomal translocation and differ only in their spectrum of neurodifferentiation. A six-year-old female peach-faced lovebird (Agapornis roseicollis) presented with an approximately 7 mm diameter mass on the inferior surface of the tongue. The bird died during cytoreductive surgery. The mass was clearly demarcated and extended broadly from the tip of the tongue to the pharynx without invasion or adhesion. Histopathologically, the mass was composed of small round cells and short spindle-shaped cells. The neoplastic cells formed Homer-Wright pseudorosettes and contained glycogen. There were numerous areas of necrosis and haemorrhage. Immunohistochemically, the tumour cells were positive for vimentin and S-100 and negative for cytokeratin, actin, glial fibrillary acidic protein, osteocalcin and secreted protein acidic and rich in cysteine (SPARC). To the authors’ knowledge, this is the first report of a peripheral primitive neuroectodermal tumour (pPNET) in a bird.

  • Ewing’s sarcoma
  • primitive neuroectodermal tumor
  • lovebird
  • tongue
  • avian
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