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Use of posaconazole for treatment of disseminated protothecosis in a dog
  1. Brittany Enders,
  2. Natasha Olby and
  3. Christopher L Mariani
  1. Department of Clinical Sciences, NCSU College of Veterinary Medicine, Raleigh, North Carolina, USA
  1. Correspondence to Dr Natasha Olby, natasha_olby{at}


A two-year-old female spayed Vizsla presented with progressive ataxia and visual deficits of three weeks’ duration and chronic intermittent large bowel diarrhoea. Protothecal organisms were identified on cytology of rectal scrapings and aspirates of intra-abdominal lymph nodes and Prototheca species were cultured from cerebrospinal fluid.

Treatment with posaconazole for two weeks yielded a marked improvement, with progression of neurological signs noted after changing to itraconazole due to cost. The dog was humanely euthanased 31 days after diagnosis. The clinical improvement produced by posaconazole in this case suggests it may be an effective therapy for this typically fatal disease, but it may currently be cost prohibitive. To the authors’ knowledge, this is the first reported use of posaconazole for treatment of disseminated protothecosis in a dog.

  • algae
  • encephalitis
  • ependymitis
  • Colitis
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  • Contributors All three authors managed the case described here and wrote and edited the paper.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement No additional data are available.

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