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Severe bradycardia after hypoxaemia and endotracheal intubation and cardiac arrest following glycopyrrolate in a dog
  1. Stefania Scarabelli,
  2. Clara Rigotti and
  3. Briony Alderson
  1. University of Liverpool School of Veterinary Science, CH647TE, Neston, UK
  1. Correspondence to Dr Stefania Scarabelli; scara{at}


A nine-year-old neutered male Yorkshire terrier with history of chronic cough underwent bronchoscopy and bronchoalveolar lavage; general anaesthesia was maintained with a variable rate infusion of propofol, and oxygen was insufflated via a urinary catheter in the trachea. At the end of the procedure, desaturation occurred; endotracheal intubation was performed and was immediately followed by severe bradycardia and respiratory arrest. Glycopyrrolate (5 µg/kg) was administered leading to cardiac arrest. Apnoea and asystole were quickly treated with manual positive pressure ventilation, external chest compressions and intravenous administration of 0.04 mg/kg of atropine. This case describes vagally induced bradycardia after intubation, possible predisposing factors and its treatment/prevention with antimuscarinic drugs.

  • Dogs
  • Anaesthesia
  • Drug administration
  • Respiratory physiology
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  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement No additional data are available.

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