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An outbreak of infectious bovine rhinotracheitis (IBR) in a herd vaccinated with a live glycoprotein E deleted (marker) bovine herpesvirus 1 (BoHV-1) vaccine: lessons to be learned
  1. Martin Stuart Tomlinson,
  2. Andy Hopker and
  3. Alexander Corbishley
  1. Farm Animal Practice, R(D)SVS, University Of Edinburgh, Easter Bush Science Campus, Roslin, Edinburgh, EH25 9RG, UK
  1. Correspondence to Martin Stuart Tomlinson; martin.s.tomlinson{at}


Vaccines are commonly used in the control of bovine respiratory disease; however, the field performance of these vaccines is poorly understood. We describe an outbreak of infectious bovine rhinotracheitis in a 383-animal beef finishing unit in Scotland four months after vaccination with a live glycoprotein E deleted (marker) bovine herpesvirus 1 (BoHV-1) vaccine. Seroconversion to the vaccine was confirmed in acute sera, and seroconversion to field virus was confirmed in convalescent sera. BoHV-1 was also identified in bronchoalveolar lavage fluid and conjunctival swabs using PCR. This outbreak highlights the importance of the reporting of veterinary vaccine suspected lack of expected efficacy events, as well as the paucity of data available to practitioners relating to the field performance of veterinary vaccines.

  • cattle
  • respiratory
  • vaccination
  • infectious bovine rhinotracheitis (IBR)
  • bovine herpes virus (BoHV)
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  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Correction notice This paper has been amended since it was published Online First. Owing to a scripting error, some of the publisher names in the references were replaced with 'BMJ Publishing Group'. This only affected the full text version, not the PDF. We have since corrected these errors and the correct publishers have been inserted into the references.

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