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Successful treatment of acute, severe hypophosphataemia in a dog
  1. John A Stewart1,
  2. Zoe A Main1 and
  3. Richard J Mellanby2
  1. 1 Wilson & Partners, 136 Bonnygate, Cupar, UK
  2. 2 Division of Veterinary Clinical Studies, University of Edinburgh, Edinburgh, UK
  1. Correspondence to Dr Richard J Mellanby; richard.mellanby{at}


Spontaneous, severe, acute hypophosphataemia is an unusual finding in dogs. This case report describes the presentation of a seven-year-old Greyhound with an acute history of polypnoea. Clinical examination revealed an increased rectal temperature, congested mucous membranes, pain on flexion of the right hindlimb and muscle fasciculations. Haematology and plasma biochemistry were generally unremarkable apart from severe hypophosphataemia and a markedly increased creatine kinase concentration. The hypophosphataemia was treated with an intravenous infusion of Toldimphos sodium, which is an organically combined phosphorus preparation. The hypophosphataemic state was rapidly corrected and clinical signs resolved over the following five days. The cause of the severe hypophosphataemia was unclear. This case demonstrates that severe, acute hypophosphataemia can be successfully treated with Toldimphos sodium infusion with a good long-term outcome even in dogs that are initially presented with debilitating clinical signs.

  • Dogs
  • Phosphate phosphorus veterinary
  • Neuromuscular disorders
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  • Contributors JAS and ZAM diagnosed and treated the dog. RJM advised on management of case. JAS and RJM cowrote the paper. JAS, ZAM and RJM approved the final manuscript.

  • Competing interests No, there are no competing interests.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement No additional data are available.

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