An adult, male, domestic longhair cat was evaluated for chronic progressive visual impairment and lethargy. Neurological abnormalities localised to the cerebellum/central vestibular system, and optic chiasm/retinas and/or optic nerves were present on clinical examination. MRI and CT studies showed diffuse hyperostosis with thickening of the calvarium and tentorium cerebelli causing compression and distortion of the brain. Biochemical testing showed low plasma retinol levels at 0.1 μmol/l (0.86–2.2). Postmortem examination showed reduction in volume of the frontal lobes secondary to diffuse skull hyperostosis. Microscopically, there were mild white matter spongiosis affecting the corona radiata and optic nerves and multiple small plaque-like thickening of the meninges. This is the first case report to provide a comprehensive clinical, diagnostic imaging and pathological details of hypovitaminosis A in a cat.
- hypovitaminosis A
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Original reference: Hypovitaminosis A in a cat: Magnetic resonance, computed tomography and histopathological findings.
Poster presentation at the 28th ECVN-ESVN Congress, 2015.
Handling editor None.
Contributors IE and DS-M were the primary clinicians of the presented case, and contributed to the design, draft and revisions of the manuscript. ER performed the postmortem examination of the presented case and contributed to the revision of the manuscript. FM reported the imaging features on the presented case and contributed to the revision of the manuscript.
Funding I confirm there are no personal financial interests or relationship with a for-profit company that either directly supports this paper or is related to this case report being conducted.
Competing interests None declared.
Patient consent Informed client consent available.
Ethics approval The owners of the presenting animal gave consent for publication of this paper. The animal here presented was treated ethically and with highest standards of professionalism.
Provenance and peer review Not commissioned; externally peer reviewed.
Data sharing statement There are no additional data available for this paper.
Press Release None.
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