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Mammals (other)
Cerebellar Purkinje cell degeneration in a mule foal (Equus mulus mulus)
  1. Anna Suñol1,
  2. Julia Sanmarti Fierro2,
  3. Greta Foiani3,
  4. Carles Morales1 and
  5. Patricia Montoliu1
  1. 1 Neurology, Ars Veterinaria, Barcelona, Spain
  2. 2 Equihealth Veterinarios, Barcelona, Spain
  3. 3 Dipartimento di Medicina Veterinaria, Università degli Studi di Perugia, Perugia, Italy
  1. Correspondence to Anna Suñol; annasunoliniesta{at}


A case of a mule foal with cerebellar Purkinje cell degeneration is described. A one-day-old mule foal was presented with lateral recumbency, obtunded mentation, poor metabolic status (general weakness, congestive mucous membranes, tachycardia, weak pulse, hypomotility and hypothermia) and cerebellar signs. After receiving medical treatment, the foal’s overall condition markedly improved but severe cerebellar ataxia and intention tremors were still present. Three weeks later, physical examination was normal but neurological signs had worsened and the foal was subjected to euthanasia. Postmortem findings revealed lesions consistent with corticocerebellar Purkinje cell degeneration. This is the first case report describing this condition in a mule.

  • mule
  • cerebellar
  • Purkinje cell degeneration
  • degenerative
  • neurons
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  • Contributors All authors were involved in the clinical workup of the case and preparation of the manuscript, and gave final approval of the manuscript.

  • Funding This research received no specific grant from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement Data is available from the corresponding author upon reasonable request.

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