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Hereditary selective cobalamin malabsorption and concurrent pancreatitis in a young Border collie
  1. Katie Elizabeth McCallum and
  2. Penny J Watson
  1. Department of Veterinary Medicine, Cambridge Veterinary School, Cambridge, UK
  1. Correspondence to Dr Katie Elizabeth McCallum; km664{at}


A one-year-old neutered male Border collie presented with failure to gain weight, lethargy, intermittent leucopenia, borderline anaemia and intermittent gastrointestinal symptoms. He was diagnosed with pancreatitis based on blood results and abdominal ultrasonography and hereditary selective cobalamin malabsorption based on hypocobalaminaemia, methylmalonic aciduria and genetic testing for cubilin mutation. The dog responded to oral cobalamin supplementation with resolution of clinical signs and normalisation of serum cobalamin. There was no recurrence of signs after 27 months of follow-up. An association between organic acidaemias and pancreatitis has been reported in humans but to the authors’ knowledge, this is the first report of hereditary selective cobalamin malabsorption and concurrent pancreatitis in a dog. Furthermore, this is the first report of inherited canine cobalamin deficiency responding to oral cobalamin supplementation.

  • pancreas
  • vitamin deficiency
  • dog

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  • Contributors KEMcC and PJW took a full part in the conception and writing of the case report.

  • Funding This research received no specific grant from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Not required.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement All data can be provided by the corresponding author upon reasonable request.

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