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Malignant melanoma with central nervous system involvement in a dog treated with surgery, radiotherapy and chemotherapy
  1. Pablo Perez Lopez1,
  2. Roberta Rasotto2,
  3. Abby Caine3 and
  4. Giunio Bruto Cherubini4
  1. 1 Roberta Rasotto Diagnostic Pathology, Dick White Referrals, Cambridgeshire, UK
  2. 2 Diagnostic Pathology, Dick White Referrals, Cambridgeshire, UK
  3. 3 Diagnostic Imaging, Dick White Referrals, Cambridgeshire, UK
  4. 4 Neurology/Neurosurgery, Dick White Referrals, Cambridgeshire, UK
  1. Correspondence to PabloPerez Lopez; pabloperezlopez{at}


A five-year-old female entire cocker spaniel was admitted for acute obtundation and non-ambulatory tetraparesis. MRI of the brain revealed a mass lesion in the right olfactory and frontal lobe area and in the right frontal sinus. Transfrontal craniotomy was performed for surgical excision, with intraoperative application of cytarabine and methotrexate. At discharge, the dog was ambulatory with mild generalised ataxia. Histopathology and immunohistochemistry revealed a malignant melanoma. Lomustine was initiated. Six months after surgery the dog was readmitted for right exophthalmos, due to a right retrobulbar mass that was surgically excised. Histopathology confirmed melanoma, and a course of radiotherapy was added and lomustine restarted. The dog was euthanased after further 17 months for relapsing neurological signs secondary to recurrent CNS melanoma. This treatment of a melanoma with CNS involvement showed encouraging results, achieving a total survival time of 23 months.

  • dogs
  • melanoma
  • frontal sinus
  • brain
  • exophthalmos
  • cytarabine
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  • Contributors All authors worked closely together in the management of this clinical case, as well as in the development of the manuscript herein.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement No additional data are available.

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