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Parathyroid immunohistochemistry in a 12-year-old mixed-breed dog with parathyroid adenocarcinoma
  1. Anna-Maria Kaiser1,
  2. Lena Kempker2 and
  3. Reto Neiger3
  1. 1 Small Animal Clinic, Justus-Liebig-Universität Giessen Fachbereich Veterinärmedizin, Giessen, Germany
  2. 2 Institute of Veterinary Pathology, Justus-Liebig-Universität Giessen Fachbereich Veterinärmedizin, Giessen, Germany
  3. 3 Tierklinik Hofheim, Hofheim, Germany
  1. Correspondence to ProfessorRetoNeiger; reto.neiger{at}


Summary A 12-year-old, female, spayed, mixed-breed dog with acute lethargy, anorexia and weakness and markedly elevated total and ionised calcium concentration showed an enlarged left cranial parathyroid gland on ultrasonography of the ventral neck. Despite preoperative therapy with furosemide and calcitonin, there was no decline of plasma ionised calcium concentration. The dog deteriorated rapidly and was euthanased two days after initial presentation. Postmortem histopathology revealed parathyroid tissue with characteristics of malignancy as local and vascular invasion. Immunohistochemistry showed parathyroid hormone positive staining of these cells. Unusual clinical presentation and histopathological characteristics are discussed.

  • hypercalcaemia
  • canine
  • immunopathology
  • parathyroid
  • hyperparathyroidism
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  • Contributors A-MK was responsible for case management, LK for pathological diagnosis and RN for case supervision. All authors wrote and corrected the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data statement There are no additional data available for this paper.

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