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Resolution of iatrogenic calcinosis cutis in a dog through topical application of DMSO
  1. Jose Maria Cifuentes Tolon1,
  2. Juan Jose Esteban Jimenez1,
  3. Iñigo Gilabert Irizar2 and
  4. Paula Casas Trasobares2
  1. 1 Department of Animal Pathology, Universidad de Zaragoza Facultad de Veterinaria, Zaragoza, Spain
  2. 2 Veterinary Clinic Cifuentes, Fuentes de Ebro, Spain
  1. Correspondence to Dr Jose Maria Cifuentes Tolon; jmcifuentes_vet{at}


A dog with calcinosis cutis was treated by topical dimethyl sulfoxide (DMSO) administration, reaching a complete involution of symptoms. DMSO is well-known for its transdermal penetration and anti-inflammatory capacity. For this reason, DMSO is proposed as a topical treatment for the management of calcinosis cutis in dogs. The authors present the clinical case of a dog with seropositive leishmaniosis and secondary immune-mediated haemolytic anaemia who was affected by intense dermatopathia on the dorsal area, diagnosed by a biopsy as calcinosis cutis. Injuries were described as necrotising ulcerative dermatitis. Currently, there are no specific treatments for its cure. The topical application of DMSO every other day was used as a unique treatment, and the use of other treatments like antibiotics or anti-inflammatory therapy was not necessary. Treating calcinosis cutis via a topical wash with DMSO every other day was effective for the symptoms of calcinosis cutis.

  • dogs
  • immune mediated diseases
  • calcinosis cutis
  • DMSO
  • dermatopathia
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  • Contributors All authors have contributed to the planning, conduct and reporting of the work described in the article.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data statement No additional data are available.

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