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Recurrent cerebrovascular accidents caused by intravascular lymphoma in a dog
  1. Lluis Sanchez1,
  2. Katrin Beckmann2,
  3. Elisabet Dominguez3,
  4. Stefano Di Palma4 and
  5. Anita Shea1
  1. 1 Neurology/Neurosurgery, Animal Health Trust, Newmarket, UK
  2. 2 Division of Neurology, Clinic for Small Animal Surgery, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland
  3. 3 Diagnostic Imaging, Animal Health Trust, Newmarket, UK
  4. 4 Pathology, Animal Health Trust, Newmarket, UK
  1. Correspondence to Lluis Sanchez; lluis.sanchez{at}


An eight-year-old, neutered male labrador was presented with recent recurrent vestibular episodes. MRI was consistent with multiple lacunar ischaemic infarcts in the thalamus and medulla oblongata. The imaging diagnosis was supported by a markedly elevated D-dimer concentration. Despite a comprehensive diagnostic workup (including fine needle cytology of cutaneous and subcutaneous nodules, complete bloodwork, urinalysis, thoracic and abdominal imaging, cerebrospinal fluid analysis, serial blood pressure measurements, echocardiography, electrocardiography and brainstem auditory evoked response testing), no underlying cause was found. After a partial response to 2  mg/kg clopidogrel once a day and 1  mg/kg prednisolone once a day, the dog acutely deteriorated and repeated MRI of the brain revealed an intra-axial haemorrhagic mass. Euthanasia was elected and postmortem examination revealed the presence of an intravascular null-cell lymphoma, exclusively in the central nervous system. Intravascular lymphoma is rare, difficult to diagnose ante-mortem and reports in veterinary literature are few.

  • dog
  • intravascular lymphoma brain
  • cerebrovascular accident
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  • Contributors LS, KB and AS were in charge of the clinical part of the case, ED was in charge of the Diagnostic Imaging part of the case and SDP was in charge of the Pathology part of the case.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement There are no additional data available.

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