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Low-dose intravenous lipid emulsion as a safe treatment for lipophilic intoxications in five cats
  1. Marco Pelizzola,
  2. Clara Mattavelli,
  3. Roberta Troìa,
  4. Elsa Murgia and
  5. Massimo Giunti
  1. Department of Veterinary Medical Sciences, University of Bologna, Bologna, Italy
  1. Correspondence to Dr Marco Pelizzola; plz.mrc{at}


The use of a low-dose infusion of intravenous lipid emulsion (ILE) in five young cats presented with acute neurotoxicity is reported. Suspected toxic compounds were permethrin (three, dermal), fipronil/eprinomectin/praziquantel (one, oral) and milbemycin (one, oral). Cats presented with acute onset of generalised tremors of variable severity. Initial treatment included toxin decontamination whenever possible, and control of neurological signs by administration of benzodiazepine and eventually a continuous rate infusion of propofol. Due to persisting clinical signs, a low-dose ILE therapy was additionally given. Discontinuation of treatment, once a resolution of neurological signs was achieved, ranged between two and nine  hours from hospital admission. All the cats fully recovered and were discharged within 18–92  hours. No side effects were noticed and follow-up was normal. The authors report the use of a low-dose infusion of ILE as an adjunctive and safe treatment for the management of lipophilic intoxications in cats.

  • cats
  • neurotoxicity
  • intravenous lipid emulsion
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  • Contributors All authors listed have contributed significantly to the work, have read the manuscript, attest to the validity and legitimacy of the data and its interpretation, and agree to its submission to Veterinary Record Case Reports. MP: design of the work, literature review and draft of the manuscript. CM: concept of work and revision of the manuscript. RT: concept of work and revision of the manuscript. EM: concept of work and revision of the manuscript. MG: design of the work, literature review, revision and final approval of the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement No additional data are available.

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