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Solitary spinal nephroblastoma progressing to multifocal disease in a dog
  1. Sonya Yu1,
  2. Karon Hoffmann2,
  3. David Taylor3 and
  4. David Lurie1
  1. 1 Department of Oncology, Animal Referral Hospital, Sydney, New South Wales, Australia
  2. 2 Imaging Vets, Sydney, New South Wales, Australia
  3. 3 Vetnostics, Sydney, New South Wales, Australia
  1. Correspondence to Dr Sonya Yu; sonyayu{at}


A two- year-old neutered Labrador dog was evaluated for acute onset hindlimb paresis and proprioceptive deficits. Spinal MRI revealed a lesion at the level of T9–T10, from which a presumptive diagnosis of spinal nephroblastoma was made. The dog showed clinical improvement after receiving neoadjuvant stereotactic radiotherapy but re-presented six  weeks later with neurological deterioration. In addition to the primary lesion, a repeat MRI study revealed lesions at T6–T7 and T12. The dog was euthanased and multiple intradural, extramedullary spinal cord lesions were found at postmortem examination. Histopathological analysis of the lesions confirmed spinal nephroblastoma. This report substantiates the likelihood of intraspinal metastases of nephroblastoma occurring in the dog.

  • oncology
  • neoplasia
  • canine
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  • Contributors SY wrote the introduction, case description and discussion KH wrote the description of the MRI and provided relevant images for this paper DT wrote the histopathological description and provided images. DL co-wrote some of the discussion.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement No additional data are available.

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