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Palliative limb-sparing photodynamic therapy with chemotherapy in a dog with osteosarcoma of the proximal tibia
  1. Tomohiro Osaki1,
  2. Yusuke Murahata1,
  3. Masamichi Yamashita1,
  4. Sakata Isao2 and
  5. Yoshiharu Okamoto1
  1. 1 Joint Department of Veterinary Medicine, Tottori University, Tottori, Japan
  2. 2 JS-Stage Inc, Okayama, Japan
  1. Correspondence to Dr Tomohiro Osaki; tosaki{at}


Canine osteosarcoma conveys a poor prognosis. This long-term follow-up report describes using photodynamic therapy with intra-arterial chemotherapy as palliation in canine osteosarcoma of the proximal tibia. A 10-year-old male Boston terrier dog presented with right hindlimb lameness; osteosarcoma of the right tibia was diagnosed. The owner chose palliative limb-sparing photodynamic therapy with intra-arterial chemotherapy. Right hindlimb lameness disappeared 24 days after the first treatment. In total, 210 days after the first treatment, post-contrast T1-weighted MRI showed a decreased gadolinium-enhancing area within the tumour. And 254 days after the first treatment, the dog underwent the tenth treatment. Then 287 days after the first treatment, abdominal radiography showed an approximately 6- cm iliac lymph node. The dog died 321 days after the first treatment; lameness did not recur. Palliative photodynamic therapy with chemotherapy can be viable and feasible in osteosarcoma of the proximal tibia; more research is needed.

  • dogs
  • intra-arterial chemotherapy
  • limb-sparing
  • osteosarcoma
  • photodynamic therapy
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  • Contributors TO wrote the initial draft of this document. TO, YM and MY have contributed substantially to the care of the animal described in this case. IS provided photosensitser. YO made final edits to the case report.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.

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