A six-year-old male neutered domestic shorthair was referred because of decreased appetite, progressive weight loss and anisocoria. Neurological examination identified a right mydriatic pupil, non-responsive to light, but no other neurological abnormalities or behavioural changes. Neuroanatomical localisation was to the right oculomotor nerve (parasympathetic component). MRI of the brain revealed a large mass affecting the meninges and intraparenchymal lesions in the cerebellum. CT of the thorax identified multiple nodules of different size within the pulmonary parenchyma and pleural and mediastinal effusion. Cytology of the pulmonary nodules revealed neoplastic cells consistent with pulmonary carcinoma, and histopathology of the meninges and brain revealed that the same epithelial population was infiltrating the meninges and the brain parenchyma. Based on these findings, meningeal carcinomatosis secondary to a suspected pulmonary carcinoma was hypothesised.
- meningeal carcinomatosis
- pulmonary carcinoma
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Contributors VC drafted the manuscript and designed the figures. YF, MO and FS developed the clinical case. SDP performed the histopathological analysis and provided the images. All authors discussed and commented on the manuscript.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Provenance and peer review Not commissioned; externally peer reviewed.
Data sharing statement No additional data are available.
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