Article Text

PDF
Other
Anaplastic meningioma in a Tasmanian devil (Sarcophilus harrisii)
  1. Jessica Elbert1,
  2. Sarah Peck2,
  3. Dane Hayes3,
  4. Jim Taylor3 and
  5. Jodi Smith4
  1. 1 College of Veterinary Medicine, Iowa State University, Ames, Iowa, USA
  2. 2 Department of Primary Industries, Parks, Water and Environment, Wildlife Management Branch, Hobart, Tasmania, Australia
  3. 3 Animal Health Laboratory, Tasmanian Department of Primary Industries, Parks, Water and Environment, Hobart, Tasmania, Australia
  4. 4 Veterinary Pathology, Iowa State University, Ames, Iowa, USA
  1. Correspondence to Dr Jodi Smith; jdismith{at}iastate.edu

Abstract

A seven-year-old male captive Tasmanian devil was euthanased after presenting with hindlimb ataxia and generalised muscle wasting. On necropsy, an irregular, cream-coloured, firm, 1 cm mass was detected on the dorsal surface of the left olfactory bulb. The mass was composed of pleomorphic neoplastic cells arranged in nests and lobules with occasional pseudorosette formation, and evinced invasion of underlying neural parenchyma. By immunohistochemistry, neoplastic cells were strongly positive for vimentin and cytokeratin AE1/AE3, variably positive for S-100 and neuron-specific enolase, and negative for calretinin, chromogranin A, synaptophysin, glial fibrillar acidic protein and neurofilament protein. Periodic acid-Schiff and Grimelius stains were also negative. Based on histopathological and immunohistochemical findings, the neoplasm was classified as an anaplastic meningioma.

  • neoplasia
  • wildlife
  • neuropathology

Statistics from Altmetric.com

Footnotes

  • Contributors JE collected, analysed and interpreted data for the work, and drafted the manuscript. SP collected antemortem data and critically revised the manuscript. DH, JT and JS (guarantor) collected, analysed and interpreted data, and critically revised the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement Underlying data from this study can be accessed by contacting the corresponding author. Data will be available immediately following publication and ending 5 years after publication.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.