A seven-year-old male captive Tasmanian devil was euthanased after presenting with hindlimb ataxia and generalised muscle wasting. On necropsy, an irregular, cream-coloured, firm, 1 cm mass was detected on the dorsal surface of the left olfactory bulb. The mass was composed of pleomorphic neoplastic cells arranged in nests and lobules with occasional pseudorosette formation, and evinced invasion of underlying neural parenchyma. By immunohistochemistry, neoplastic cells were strongly positive for vimentin and cytokeratin AE1/AE3, variably positive for S-100 and neuron-specific enolase, and negative for calretinin, chromogranin A, synaptophysin, glial fibrillar acidic protein and neurofilament protein. Periodic acid-Schiff and Grimelius stains were also negative. Based on histopathological and immunohistochemical findings, the neoplasm was classified as an anaplastic meningioma.
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Contributors JE collected, analysed and interpreted data for the work, and drafted the manuscript. SP collected antemortem data and critically revised the manuscript. DH, JT and JS (guarantor) collected, analysed and interpreted data, and critically revised the manuscript.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Provenance and peer review Not commissioned; externally peer reviewed.
Data sharing statement Underlying data from this study can be accessed by contacting the corresponding author. Data will be available immediately following publication and ending 5 years after publication.
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