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Uncommon thalamic metastasis of an osteosarcoma causing central diabetes insipidus in a young barsoi dog
  1. Martina Dettwiler1,
  2. Nicole Borel2,
  3. Sandra Schäfer3,
  4. Daniel Ivan3 and
  5. Monika Hilbe2
  1. 1 Department for Infectious Diseases and Pathobiology, Institut fur Tierpathologie, Universitat Bern, Bern, Switzerland
  2. 2 Institute of Veterinary Pathology, Zurich, Switzerland
  3. 3 Department fur Kleintiere, Universitat Zurich, Zurich, Switzerland
  1. Correspondence to Dr Monika Hilbe; hilbe{at}


A five-year-old male barsoi dog presented with lameness of the left hindlimb. Radiographs, CT and MRI studies revealed a mono-ostotic aggressive bone lesion in the proximal tibial metaphysis expanding into the epiphysis, complicated by a pathological fracture. Conservative treatment was pursued. Two months later, the dog was presented again to our clinic, now in comatose state. Brain MRI detected a large intra-axial space-occupying lesion in the thalamic region. The dog was euthanased. Necropsy revealed a mass in the left proximal tibial epiphysis and metaphysis and a bony mass in the pituitary region compressing the surrounding nervous tissue. Histologically, both masses were diagnosed as osteosarcoma, most likely chondroblastic type. The metastatic brain mass infiltrated the thalamus, hypothalamus and pituitary stalk, causing disruption of ADH synthesis and/or transport. This is an uncommon case of a clinically manifest central diabetes insipidus caused by a metastatic osteosarcoma.

  • dogs
  • histopathology
  • imaging
  • neuropathology
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  • Contributors MH and MD made the draft and correction. MD made the necropsy. NB was the supervisor of the necropsy and corrected the manuscript. DI did the imaging and corrected the manuscript. SS made the clinical examination and corrected the manuscript.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement No additional data are available.

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