Article Text

Download PDFPDF
Imaging and histopathological characteristics of carcinoma-induced bone formation in skeletal muscle
  1. Brooke Luce1,
  2. Michelle Magagna2,
  3. Rachel Policelli Smith1 and
  4. Paulo Vilar Saavedra1
  1. 1 Small Animal Clinical Sciences, Michigan State University, East Lansing, Michigan, USA
  2. 2 Michigan State University Veterinary Diagnostic Laboratory, East Lansing, Michigan, USA
  1. Correspondence to Dr Paulo Vilar Saavedra; psaavedr{at}


An 11-year-old neutered male Groenendael canine presented with suspected neoplastic disease associated with pelvic limb lameness. Clinical examination revealed firm and thickened ventral abdominal musculature, pitting oedema with a spiculated texture within pelvic limb and inguinal subcutaneous tissues, sublumbar lymphadenopathy and multifocal hard foci along the floor of the pelvic canal. CT revealed a severe active polyostotic periosteal reaction and muscular mineralisation of the hindlimbs and caudal trunk. Skeletal muscle biopsy revealed a histopathological diagnosis of metastatic carcinoma with chondroid osseous metaplasia characterised by ossification (bone formation) within the tissue matrix. Paliative therapy was provided for the dog for two weeks before being euthanized.

  • Neoplasia
  • musculoskeletal
  • computed tomography (CT)
  • carcinoma
  • metastasis
View Full Text

Statistics from


  • Contributors Conception and design: BL and PVS. Acquisition of data: BL, PVS and MM. Analysis and interpretation of data: BL, PVS, MM and RPS. Drafting the article: BL, PVS, MM and RPS. Revising article for intellectual content: BL, PVS, RPS and MM. Final approval of the completed article: BL, PVS, RPS and MM.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sector.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement No additional data are available.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.