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Use of regional limb perfusion with amikacin sulphate in the treatment of a severe soft tissue infection in the extremity of a dog
  1. Brittany E Abrams1,
  2. Heidi Hottinger2 and
  3. Laura Elizabeth Selmic1
  1. 1 Department of Veterinary Clinical Sciences, The Ohio State University, College of Veterinary Medicine, Columbus, Ohio, USA
  2. 2 Gulf Coast Veterinary Specialists, Houston, Texas, USA
  1. Correspondence to Dr Laura Elizabeth Selmic; laura.selmic{at}


Intravenous regional limb perfusion (RLP) has been used extensively in equine and human practice to deliver high doses of antimicrobials to bones, joints and the soft tissues in the distal limb. This report highlights the use of this technique, in conjunction with traditional systemic antimicrobial therapy, to achieve clinical resolution of a severe soft tissue infection in the extremity of a dog. Due to the acute severity, rapid progression and lack of response of the infection to broad-spectrum systemic antibiotics, intravenous RLP with amikacin was utilised successfully, negating the need to intervene with definitive surgery. To the authors’ knowledge, this is the first report utilising intravenous RLP as an adjuvant antimicrobial treatment application in a small animal setting.

  • bacterial diseases
  • clinical practice
  • companion animals
  • dogs
  • drug administration
  • infectious diseases
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  • Contributors All authors contributed to the intellectual ideas and to the manuscript draft presented.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement No additional data are available.

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