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Dogs
Leishmaniosis manifesting as osteomyelitis and monoarthritis in a dog and outcome following treatment with miltefosine and allopurinol
  1. Maya Laura König1,
  2. Judith Howard2,
  3. Marta Schmidhalter3,
  4. Brigitte Hentrich4 and
  5. Bianca Hettlich5
  1. 1 Department of Veterinary Clinical Medicine, Small Animal Clinic, Vetsuisse-Faculty, University of Bern, Bern, Switzerland
  2. 2 Department of Veterinary Clinical Medicine, Clinical Diagnostic Laboratory, Vetsuisse-Faculty, University of Bern, Bern, Switzerland
  3. 3 Department of Clinical Radiology, Vetsuisse-Faculty, University of Bern, Bern, Switzerland
  4. 4 Department of Veterinary Parasitology, Vetsuisse-Faculty, University of Bern, Bern, Switzerland
  5. 5 Department of Veterinary Clinical Medicine, Small Animal Clinic, Vetsuisse-Faculty, University of Bern, Bern, Switzerland
  1. Correspondence to Dr Bianca Hettlich; bianca.hettlich{at}vetsuisse.unibe.ch

Abstract

A nine-year-old male, neutered, mixed-breed dog was presented with chronic left pelvic limb lameness, moderate muscular atrophy and pain on palpation of the lateral femoral condyle. No other clinical abnormalities were found except for two subcutaneous tarsal nodules. Radiographs and CT revealed severe stifle monoarthropathy and distal femoral osteolysis without periosteal proliferation, mild popliteal lymphadenopathy and several small splenic nodules. Leishmaniosis was diagnosed on cytology of the lymph nodes and spleen, serology and PCR of the synovial membrane, and bone biopsies. Complete clinical remission was achieved with oral miltefosine and allopurinol. The areas of distal femur bone loss remained radiographically and on CT. Monarthritis and osteomyelitis without systemic clinical signs or clinicopathological alterations have rarely been reported with canine leishmaniosis. Leishmaniosis should be considered even if radiographic signs are atypical. Treatment with miltefosine and allopurinol was successful in achieving clinical remission. Previous areas of bone loss remained quiescent without bone infilling.

  • dog
  • leishmaniasis
  • osteomyelitis
  • monoarthritis

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Footnotes

  • Contributors MLK: clinical case management, drafting and revision of the manuscript. JH: responsible for cytological and laboratory assessment, review of the manuscript. MS: responsible for diagnostic imaging assessment, review of the manuscript. BrH: responsible for parasitological assessment, review of the manuscript. BiH: clinical case management, contribution to and review of the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement No additional data are available.

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