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Magnetic resonance findings in a Cavalier King Charles spaniel with osteopetrosis, Chiari-like malformation and syringomyelia
  1. Ricardo Fernandes1,
  2. C J Jordan2 and
  3. Colin Driver3
  1. 1Fitzpatrick Referrals, Bramley, UK
  2. 2Tri Lake Hospital and Referral Centre, Lake Country, British Columbia, Canada
  3. 3Neurology, Fitzpatrick Referrals, Godalming, UK
  1. Correspondence to Ricardo Fernandes; ricfer82{at}


Osteopetrosis (OP) is a rare genetic condition characterised by osteoclast impairment, deficient bone remodelling and increased bone density. Human patients with OP often present with fractures, osteomyelitis, anaemia, abnormal skeletal development, cranial nerve compression and rarely increased intracranial pressure secondary to craniosynostosis and/or calvarial thickening. A 17-month-old male neutered Cavalier King Charles spaniel was presented for evaluation of occasional painful vocalisation. MR of the brain and the vertebral column revealed a rare association of Chiari-like malformation (CLM) and calvarial thickening due to diffuse OP resulting in severe cerebellar compression and herniation into the foramen magnum. To the authors’ knowledge, this report represents the first described case of calvarial thickening caused by OP in association with CLM and syringomyelia in veterinary medicine.

  • osteopetrosis
  • Chiari-like malformation
  • magnetic resonance imaging (MRI)
  • Cavalier King Charles spaniel
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  • Contributors This was originally seen by RF under the supervision of CD. The radiographs were reviewed by CJ. This manuscript was written by RF as part of the scientific publications required for the European College of Veterinary Neurology credentials and reviewed by CJ and CD.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement No additional data are available.

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