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Amphibians, reptiles and fish
Chromatophoroma in a Siamese fighting fish (Betta splendens)
  1. Chelsea Ciambrone1,
  2. Laura R Chen2,
  3. Debra A Tokarz2 and
  4. Gregory A Lewbart3
  1. 1University of Illinois at Urbana-Champaign College of Veterinary Medicine, Urbana, Illinois, USA
  2. 2Population Health and Pathobiology, North Carolina State University College of Veterinary Medicine, Raleigh, North Carolina, USA
  3. 3Clinical Sciences, North Carolina State University, Raleigh, North Carolina, USA
  1. Correspondence to Dr Gregory A Lewbart; galewbar{at}


An adult male blue Siamese fighting fish (Betta splendens) presented to the North Carolina State University College of Veterinary Medicine with a cranial mass located dorsal to his right eye. A fine-needle aspiration was performed followed by supportive care. Due to the patient’s small size aggressive treatment was not elected. The mass continued to expand over a course of five months until the patient was found deceased, and a postmortem examination was performed. Histopathology determined the mass to be a chromatophoroma of the iridophoroma or leucophoroma subtypes. This is the first documentation of a chromatophoroma in B splendens.

  • Betta splendens
  • chromatophoroma
  • neoplasia
  • histopathology
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  • Contributors CC wrote the manuscript. LRC and DAT reviewed the pathology and wrote portions of and edited the manuscript. GL was the clinician on the case, coordinated the efforts and edited the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement No additional data are available.

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