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Delayed hypersensitivity reaction to human serum albumin in a dog surgically managed for septic peritonitis
  1. Mike Hubers1,
  2. Asher Allison2 and
  3. Rosario Vallefuoco1
  1. 1Small Animal Surgery, Pride Veterinary Centre, Derby, UK
  2. 2Anaesthesia, Pride Veterinary Centre, Derby, UK
  1. Correspondence to Mike Hubers; mikehubers123{at}


A five-year-eight-month-old standard poodle presented with hypovolaemic shock and severe jaundice. The dog was diagnosed with a perforating pyloric ulcer and treated surgically with pylorectomy and gastroduodenostomy. During the recovery phase the dog developed peripheral oedema secondary to severe hypoalbuminaemia (14 g/l). Treatment of the hypoalbuminaemia included a human serum albumin (HSA) transfusion. The patient was readmitted nine days post-transfusion with pyrexia, petechiae, scleral bleeding, anorexia, oedema and forelimb lameness. A presumptive diagnosis of a type 3 hypersensitivity reaction to the HSA transfusion was made. The dog was treated with 0.5 mg/kg prednisolone twice daily, 20 mg/kg pentoxifylline three times a day and 1 mg/kg omeprazole twice daily. Clinical signs resolved within one week, and at the last follow-up, five months postsurgery, the owners reported that the dog was clinically well with no further signs of side effects from the HSA transfusion.

  • pyloric ulceration
  • human serum albumin
  • type 3 hypersensitivity reaction
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  • Contributors The original case was managed by RV, MH and AA. The main manuscript was written by MH under the supervision and guidance of RV and AA. The text has been reviewed and amended by all three authors before resubmission.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement All data relevant to the study are included in the article or uploaded as supplementary information.

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