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Severe persistent canine oral papillomatosis a multimodal approach including interferon alpha-2B, CPV-1 autologous vaccine, CO2 laser ablation and aggressive cryotherapy
  1. Matthew Levinson1,
  2. Allison Kirby2,
  3. Austin Richman2 and
  4. Melissa Hall1
  1. 1Animal Dermatology Clinic, Tustin, California, USA
  2. 2Animal Dermatology Clinic, Marina Del Rey, California, USA
  1. Correspondence to Dr Matthew Levinson; mlevinson{at}


A 3-year-old, 29.5 kg female, spayed, labrador retriever cross with a 5-month history of severe, persistent papillomas affecting the oral mucous membranes was successfully treated using a multimodal approach that included staged aggressive cryotherapy. On presentation, verrucous growths varying in sizes of 2 mm–3 cm were appreciated affecting all tissues of the oral cavity. There were two alopecic, pedunculated growths with frond-like projections approximately 4 mm by 4 mm and 1 cm by 4 mm on the left pelvic paw. While the growths on the paws resolved with minimal intervention, the oral verrucous growths remained. A combination of interferon alpha-2B, canine papillomavirus-1 autologous vaccine, surgical excision, carbon dioxide laser ablation and aggressive cryotherapy led to complete resolution and continued remission of the canine oral viral papillomas.

  • canine papilloma virus
  • cryotherapy
  • dogs
  • dermatology
  • viruses
  • vaccines
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  • Contributors All authors involved contributed in the planning, conducting and reporting of this case report. LM contributed to the planning, conducting the treatments and writing the case report. AK, AR and MH were all equally involved in some of the planning and conducting of the treatments. They all had contributions in the reporting as well.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement No additional data are available.

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