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Duodenal ganglioneuromatosis causing common bile duct obstruction in a dog
  1. Pauline Deprez1,
  2. Jean-Guillaume Grand2 and
  3. Nathaniel Harran1
  1. 1Department of diagnostic imaging, Aquivet Clinique Veterinaire, Eysines, France
  2. 2Department of surgery, Aquivet Clinique Veterinaire, Eysines, France
  1. Correspondence to Dr Pauline Deprez; p.deprez{at}


A 3-year-old intact female labrador retriever dog was presented for anorexia, weight loss and vomiting. Abdominal ultrasonography revealed a mass of the descending duodenum involving the major duodenal papilla with loss of the normal intestinal wall layering. The distal part of the common bile duct was circumferentially thickened obliterating its lumen and causing extrahepatic biliary obstruction. Exploratory laparotomy was undertaken, total descending duodenum excision with gastrojejunostomy, cholecystojejunostomy and pancreaticojejunostomy procedures were performed. The dog died 3 days postoperatively. Histopathological and immunohistochemistry examinations of the specimens from the duodenectomy demonstrated multinodular to diffuse intestinal ganglioneuromatosis. This is the first reported case of an intestinal ganglioneuromatosis, a rare hyperplastic proliferation of ganglion cells and nerves of the enteric autonomic nervous system, involving the duodenum and causing extrahepatic biliary obstruction.

  • dogs
  • intestinal disease
  • abdominal
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  • Contributors All authors contributed to the study performed here which represents a single descriptive case report.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement No additional data are available.

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