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Osteopetrosis in a young adult dog causing multiple cranial nerve deficits
  1. James Elford1,
  2. Andrew T Parry2 and
  3. Sebastien Behr1
  1. 1Neurology Service, Willows Veterinary Centre and Referral Centre, Solihull, UK
  2. 2Diagnostic Imaging, Willows Veterinary Centre and Referral Centre, Solihull, UK
  1. Correspondence to James Elford; james.elford{at}


A two-year-old Cocker Spaniel was presented for investigation of lethargy and cranial nerve deficits. Neurological examination revealed multiple cranial nerves deficits and haematology and serum biochemistry revealed mild anaemia. MRI of the brain revealed caudoventral cerebellar herniation and cervical syringohydromyelia, while both MRI and CT revealed hyperostosis of the calvarium and narrowing of the calvarial foramina. Radiographs demonstrated marked osteosclerosis of the skull, vertebrae, sternebrae, ribs and long bones of the limbs. Further biochemistry revealed total calcium, ionised calcium and vitamin D levels to be unremarkable. This led to a diagnosis of osteopetrosis. Osteopetrosis is an extremely rare condition in dogs, with only sporadic cases being reported previously in the literature.

  • Osteopetrosis
  • Neurology
  • Neuroimaging
  • Anaemia
  • Stenotic foramina
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  • Contributors JE: wrote the manuscript. SB: primary clinician and supervision of the case report writing. ATP: supplied the images, reviewed the imaging finding and reported the case.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement All data relavent to the study are included in the article or uploaded as supplementary information.

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