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Chloramphenicol-associated megaoesophagus in a dog
  1. Bradley Bishop and
  2. Stuart Walton
  1. Department of Small Animal Clinical Sciences College of Veterinary Medicine, University of Florida, Gainesville, Florida, USA
  1. Correspondence to Dr Stuart Walton; stuartawalton{at}


A three-year-old spayed female Belgian malinois that was being treated with chloramphenicol for Corynebacterium-associated encrusted cystitis for seven weeks was evaluated for regurgitation, change in bark, hindlimb ataxia and anorexia. Thoracic radiographs revealed a severely, diffusely dilated oesophagus. Acetylcholine receptor antibody testing was negative. Chloramphenicol administration was discontinued and within five weeks of discontinuing the medication, the regurgitation ceased, ataxia resolved and appetite returned to normal. Thoracic radiographs were performed four months later revealing resolution of the previously observed megaoesophagus. This case suggests that chloramphenicol may be associated with the development of reversible megaoesophagus and peripheral neurotoxicity in dogs.

  • megaoesophagus
  • neuropathy
  • canine
  • chloramphenicol
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  • Contributors Both authors BB and SW have substantial contributions to the conception, drafts and revising of this paper. Both authors have approved the final draft being submitted and are accountable for all aspects of the work submitted.

  • Funding This research received no specific grant from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement All data relevant to this case report is included in the article.

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