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Hypoglycaemia associated with gastrointestinal and extragastrointestinal stromal tumour in two dogs
  1. Joanna Lodzinska1,
  2. Clara Ballber2,
  3. Sionagh H Smith3 and
  4. Spela Bavcar1
  1. 1Hospital for Small Animals, University of Edinburgh Royal Dick School of Veterinary Studies, Easter Bush, UK
  2. 2Wood Street Veterinary Hospital, Barnet, UK
  3. 3Veterinary Pathology Unit, University of Edinburgh, Edinburgh, UK
  1. Correspondence to Dr Joanna Lodzinska; jlodzins{at}


Gastrointestinal stromal tumours (GISTs) are uncommon mesenchymal tumours that originate from the interstitial cells of Cajal. As these tumours are difficult to distinguish from gastrointestinal smooth muscle tumours using standard histological techniques, their true prevalence may be underestimated. Metabolic and systemic consequences of GISTs are not well described in any species. More rarely, neoplasms with histological and immunohistochemical features similar to GISTs may occur outside the gastrointestinal tract, the so-called extragastrointestinal stromal tumours (EGIST). EGISTs have never been described in the veterinary literature. In this article the authors present and describe clinical findings, management and treatment of two dogs with clinical hypoglycaemia induced by histologically confirmed GIST and EGIST. Hypoglycaemia resolved immediately and long term after tumour excision. To the authors’ knowledge this is the first report of hypoglycaemia associated with a canine GIST and the first case report of an EGIST in a dog.

  • dogs
  • Computed tomography (CT)
  • ultrasonography
  • GIST
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  • Contributors Conception and design: JL, CB. Acquisition of data: JL, SHS. Analysis and interpretation of data: JL, CB, SHS, SB. Drafting the article: JL, CB. Revising the article for intellectual content: JL, CB, SHS, SB. Final approval of the completed article: JL, CB, SHS, SB.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement Data are available upon request.

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