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Dogs
Atypical hypoadrenocorticism in a dog with chronically elevated serum alanine aminotransferase (ALT) activity
  1. Olivia Murray1 and
  2. Yuri A Lawrence2
  1. 1Department of Small Animal Clinical Sciences, Texas A&M University College Station, College Station, Texas, USA
  2. 2Gastrointestinal Laboratory, Texas A&M University College Station, College Station, Texas, USA
  1. Correspondence to Dr Yuri A Lawrence; yuri.lawrence{at}austinvets.com

Abstract

A 10-year-old male, castrated, Beagle dog was presented for subclinical, chronic elevated serum alanine aminotransferase activity on serial serum biochemistry profiles. Additionally, mild hypocholesterolaemia, hypoalbuminaemia and hyperammonaemia were identified. Microhepatica was noted on abdominal ultrasound and cytologic examination of a liver aspirate indicated hepatocellular atypia. A laparoscopic liver biopsy was performed and the patient was discharged the same day. The following day, the patient presented to the emergency service for an acute onset of severe vomiting. The patient was treated symptomatically and an adrenocorticotrophic hormone stimulation test and aldosterone assay were diagnostic for atypical hypoadrenocorticism. Although hypoadrenocorticism is known for its vague clinical signs, it is an uncommon disease. This case was further complicated by an unusual signalment.

  • endocrinology
  • hypoadrenocorticism
  • hepatic disease
  • canine chronic hepatitis
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Footnotes

  • Contributors OM was involved in analysis of patient data, drafting and revision of the report. YL was involved in initial collection of patient data, analysis of patient data, drafting and revision of the report.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement All data relevant to the study are included in the article.

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