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Suspected anaphylaxis after intravenous administration of cefuroxime (Zinacef) in two dogs, with descriptions of arterial blood gas abnormalities over time
  1. Hannah Leigh,
  2. Hulda Harðardottir,
  3. Gudrun Schöffmann and
  4. Ambra Panti
  1. College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, UK
  1. Correspondence to Hannah Leigh; hleigh{at}


Two cases of suspected anaphylaxis occurred in the authors’ hospital within two weeks of each other. The first, a six-year-and-four-month-old border collie, presented for thoracic wall resection. Once anaesthetised, 20 mg/kg of intravenous cefuroxime (Zinacef 75 mg/ml, GlaxoSmithKline UK) was administered slowly for prophylactic antibiosis. Ten minutes after administration was completed,desaturation occurred alongside tachycardia, hypotension and apnoea. Chest compliance was extremely poor, with minimal chest movement. Treatment included intermittent positive pressure ventilation, intravenous fluids, terbutaline, adrenaline and dexamethasone. The second case, a five-year-and-eight-month-old Lhasa apso, presented for elective orthopaedic surgery. Intravenous cefuroxime (Zinacef 75 mg/ml) was again administered slowly for prophylactic antibiosis; however, it is uncertain whether the patient received the full dose of 20 mg/kg. Mid-administration tachycardia, tachypnoea and hypotension occurred,alongside poor chest compliance. Cefuroxime administration was stopped, the fluid line disconnected and treatment with chlorphenamine given.

  • dogs
  • anaesthesia
  • antimicrobials
  • allergy
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  • Contributors HL and HH were the anaesthetists for the cases described. GS and AP suggested writing them as a case report. HL wrote the manuscript with support from HH, AP and GS. All authors critically reviewed and approved the final manuscript before submission.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement All data relevant to the study are included in the article.

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