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Conformal hypofractionated radiotherapy for dogs with large adrenal tumours
  1. Takuya Maruo1,
  2. Tetsuro Ito2,
  3. Eiichi Kanai3,
  4. Yuki Nemoto2 and
  5. Yuta Nishiyama2
  1. 1 Laboratory of Veterinary Radiology, Department of Veterinary Medicine, Azabu University, Sagamihara, Japan
  2. 2 Veterinary Teaching Hospital, Azabu University, Sagamihara, Japan
  3. 3 Laboratory of Small Animal Surgery, Department of Veterinary Medicine, Azabu University, Sagamihara, Japan
  1. Correspondence to Dr Takuya Maruo; maruo{at}


Adrenalectomy has been recognised as the treatment of choice for adrenal tumours. However, excision of large tumours with or without vena caval tumour thrombi is difficult. The purpose of this case series was to describe the use of 3D conformal hypofractionated radiotherapy for unresectable adrenal tumours (over 7 cm long) in three dogs (bulldog, shih tzu and miniature dachshund). The tumours had invaded the caudal vena cava in two of the dogs. The irradiation protocols included 23.7 Gy/three fractions/three weeks or 26 Gy/four fractions/four weeks. Following the treatment, tumours in two cases showed a 34 and 40 per cent reduction in size. No radiation-related adverse events were detected. Metastatic lesions developed in all cases. The overall survival in the three dogs was 19, 25 and 27 months. Therefore, 3D conformal hypofractionated radiotherapy can treat adrenal tumours without severe complications, and prolong the survival in dogs.

  • hypofractionated radiotherapy
  • dogs
  • adrenal tumour

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  • Contributors TM and YN were responsible for RT management and diagnostic imaging. EK, TI and YN were responsible for case follow-up. All authors wrote and corrected the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement Data are available upon request.

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