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High-grade astrocytoma with ventricular invasion in a dog
  1. Rayane Chitolina Pupin1,
  2. Daniel R Rissi2,
  3. Danilo Carloto Gomes1,
  4. Amanda Gimelli3 and
  5. Mariana Isa Poci Palumbo4
  1. 1Anatomic Pathology Laboratory, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brazil
  2. 2Department of Pathology and Athens Veterinary Diagnostic Laboratory, University of Georgia College of Veterinary Medicine, Athens, Georgia, USA
  3. 3Professional Residence in Veterinary Medicine, Federal University of Mato Grosso do Sul, Campo Grande, Brazil
  4. 4Small Animal Medical Clinic, Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil
  1. Correspondence to Rayane Chitolina Pupin; rayane.pupin{at}


A 13-year-old female German Shepherd dog was euthanised and submitted to necropsy after a 7-month history of prolonged recumbency and vocalisation. Gross anatomical changes consisted of a well-demarcated, 3.5×1.5 cm, soft red mass that effaced the right lateral ventricle and compressed the adjacent neuroparenchyma. Histologically, elongate neoplastic cells with astrocytic morphology were arranged in short bundles and streams supported by a neuropil-like stroma. Neoplastic cells were immunopositive for glial fibrillar acidic protein (GFAP) and oligodendrocyte transcription factor 2 (Olig2), and immunonegative for e-cadherin and pancytokeratin. Histological and immunohistochemical features were consistent with a high-grade astrocytoma with ventricular invasion, a rare feature of astrocytic tumours in dogs.

  • intraventricular tumours
  • immunohistochemistry
  • glioma
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  • Contributors All the authors contributed to the final diagnosis and writing of the paper.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement Data are available upon request.

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