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Ependymoma arising from the third ventricle mimicking optic neuritis in a dog
  1. Abbe Harper Crawford1,
  2. Simon Spiro2,
  3. Kenneth C Smith3 and
  4. Elsa Beltran4
  1. 1Department of Clinical Science and Services, Royal Veterinary College Clinical Services Division, Hatfield, UK
  2. 2Anatomic Pathology, Royal Veterinary College, London, UK
  3. 3Department of Pathology and Infectious Diseases, Royal Veterinary College, Hatfield, UK
  4. 4Department of Clinical Science and Services, Royal Veterinary College, North Mymms, Hatfield, UK
  1. Correspondence to Dr Abbe Harper Crawford; ahcrawford{at}


Neurological examination of a 4.5-year-old female neutered labrador retriever was consistent with a lesion in the subcortical visual pathway (mainly affecting the left retina or optic nerve, and less likely the optic chiasm or right optic tract). Ophthalmic examination was unremarkable. MRI revealed enlargement of the left optic nerve and optic chiasm. A presumptive diagnosis of immune-mediated optic neuritis was made and immunosuppressive therapy was commenced. The dog re-presented 14 days later due to progressive deterioration and generalised seizure activity, and was euthanased. Postmortem examination revealed an anaplastic ependymoma extending from the rostral thalamus along the left optic nerve. Ependymoma can therefore mimic an optic neuropathy, such as immune-mediated optic neuritis, and should be considered as a differential diagnosis.

  • optic nerve
  • Magnetic resonance imaging (MRI)
  • ependymoma
  • optic neuritis
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  • Contributors All authors contributed to the management of the clinical case, as well as to planning, writing and editing of this manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement All data relevant to the study are included in the article.

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