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Management of presumptive canine permethrin toxicosis using intravenous lipid emulsion as an adjunctive therapy
  1. Matthew A Kopke and
  2. Ivayla D Yozova
  1. School of Veterinary Science, Massey University, Palmerston North, New Zealand
  1. Correspondence to Dr Matthew A Kopke; m.kopke{at}


A seven-month-old Cavalier King Charles spaniel presented with generalised, coarse muscle tremors that progressed to seizure activity, after observed ingestion (licking) of a cleaning product containing permethrin. At the time of presentation, the dog was receiving prednisone as management for masticatory muscle myositis. The dog was treated with symptomatic and supportive therapy in the form of midazolam, dexmedetomidine and intravenous lipid emulsion (ILE). This case details the first reported use of ILE as adjunctive therapy in the successful management of canine permethrin toxicosis. No further tremors or seizure activity, nor any adverse effects were observed following administration of ILE therapy.

  • canine
  • ILE
  • intoxication
  • seizures
  • tremors
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  • Contributors MAK: extensively involved with the case management and drafted the manuscript. IDY: involved with case management and manuscript review.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement All data relevant to the study are included in the article.

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