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Severe bronchoconstriction as part of a suspected anaphylactic reaction in a dog following administration of gadobutrol
  1. Philippa Kate Tucker1 and
  2. Paul Macfarlane2
  1. 1Anaesthesia, University of Bristol, Langford, Somerset, UK
  2. 2Anaesthesia, Langford Veterinary Services, Langford, Somerset, UK
  1. Correspondence to Philippa Kate Tucker; pt16723{at}


A four-year-and-three-month-old Jack Russell terrier presented for investigation of acute-onset paraplegia, with an MRI performed under general anaesthesia. Following administration of a gadobutrol contrast medium, apnoea, cyanosis, resistance to ventilation, hypotension and tachycardia were observed. An anaphylactic reaction was suspected, characterised by severe bronchoconstriction and cardiovascular collapse. This was treated with multiple isotonic crystalloid fluid boluses, intermittent positive pressure ventilation, terbutaline and cessation of general anaesthesia. Following recovery from general anaesthesia, continuous positive airway pressure and later high-flow nasal oxygen therapy were needed to treat severe hypoxaemia. Treatment of the acute anaphylactic reaction was successful; however, the dog was euthanased due to progressive neurological disease.

  • anaesthesia
  • bronchoconstriction
  • anaphylaxis
  • gadolinium
  • continuous positive airway pressure
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  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement There are no data in this work.

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