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Mammals (other)
Multiple successful tiletamine-zolazepam-xylazine immobilizations in an Amur tiger cub
  1. Julio A Mercado1,
  2. Jacobo Romano2,
  3. Horacio De la Cueva3 and
  4. Paulina Haro4
  1. 1Animal Health, Universidad Autonoma de Baja California Instituto de Investigaciones en Ciencias Veterinarias, Mexicali, Baja California, Mexico
  2. 2Medicina Veterinaria, Zoologico Parque Morelos, Tijuana, Baja California, Mexico
  3. 3Biología de la Conservación, Centro de Investigacion Cientifica y de Educacion Superior de Ensenada, Ensenada, Baja California, Mexico
  4. 4Laboratorio de Parasitologia, CONACYT-Centro de Investigaciones Regionales Dr Hideyo Noguchi, Universidad Autónoma de Yucatán, Mérida, Yucatán, Mexico
  1. Correspondence to Dr Julio A Mercado; juliomr{at}


Tiletamine-zolazepam immobilisation use in tigers is controversial and has been associated with neurological diseases, poor recoveries and death. Recent publications show this controversy is unsubstantiated. The multiple use of the tiletamine-zolazepam-xylazine (TZ-XZ) combination in a 33-kg Amur tiger (Panthera tigris altaica) cub without adverse reactions is described. The physiological values were not statistically different between anaesthetic events and were comparable with those observed with other protocols. No renal, hepatic or neurological functions were affected during the 10 anaesthetic events over the course of five months. The TZ-XZ (1–1.5 mg/kg + 0.5–1 mg/kg) combination proved to be safe for use in this tiger during repeated immobilisations. The tiger was healthy at the time of the paper’s submission. Further studies with a larger population of animals are encouraged.

  • anaesthesia
  • blood pressure
  • zoo animals
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  • Contributors All authors have contributed in different ways to this article, enriching the methodology and statistics and in writing the article.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement All data relevant to the study are included in this article.

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